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A Site-to-Site VPN connection helps you establish a secure connection from an enterprise datacenter to the cloud infrastructure. This allows users to access the guest VMs by establishing a VPN connection to the virtual router of the account from a device in the datacenter of the enterprise. Having this facility eliminates the need to establish VPN connections to individual VMs. The difference from Remote VPN is that Site-to-site VPNs connects entire networks to each other, for example, connecting a branch office network to a company headquarters network. In a site-to-site VPN, hosts do not have VPN client software; they send and receive normal TCP/IP traffic through a VPN gateway. The supported endpoints on the remote datacenters are: Cisco ISR with IOS 12.4 or later Juniper J-Series routers with JunOS 9.5 or later In addition to the specific Cisco and Juniper devices listed above, the expectation is that any Cisco or Juniper device running on the supported operating systems are able to establish VPN connections. To set up a Site-to-Site VPN connection, perform the following: Create a Virtual Private Cloud (VPC). See . Create a VPN Customer Gateway. Create a VPN gateway for the VPC that you created. Create VPN connection from the VPC VPN gateway to the customer VPN gateway.